Everything about ceesdekker.net
Everything about ceesdekker.net
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‘The 2nd is nanopores, which is our oldest line of research and that has now triggered DNA sequencers based on nanopores. We pull person DNA strands through a nanopore and can then read from the nucleotide sequence. Incredibly a short while ago, we even managed to examine out one protein for The 1st time working with This method. But this line of analysis is not just about developing applications, but will also about authentic biological concerns.
Human Rad51 filaments on double- and one-stranded DNA: correlating normal and irregular kinds with recombination function.
‘It absolutely was basically a issue of choosing up a book on mobile biology and beginning to study. I'd originate from a globe of extremely-substantial vacuums, cryostats and quantum phenomena, and now I was working at place temperature with molecular biology kits.
Sculpting nano-electrodes having a transmission electron beam for electrical and geometrical characterization of nanoparticles.
2010, formulated a new way (‘wedging transfer’) to manipulate nanostructures; very first report of DNA translocation by way of graphene nanopores; and recognized hybrid nanopores by directed insertion of α-hemolysin into stable-point out nanopores
SMC complexes can move physical roadblocks bigger than their ring sizing, indicating a nontopological system for DNA loop extrusion
Numerous connected developments followed, in which our group proven diverse transistor variants for example solitary-electron transistors at area temperature and intramolecular nanotube junctions that acted as rectifying diodes, and coupled a number of transistors into modest evidence-of-theory electronic circuits.
Studying DNA loop extrusion by SMC proteins for chromosome architecture with solitary-molecule assays.
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Incredibly awesome, but that wasn’t genuinely where my curiosity lay. I planned to pioneer And that i had the feeling which was now not possible, since the most appealing fundamental insights had previously been uncovered. But my industry experienced created a lot of exciting new resources to evaluate particular person molecules. I made a decision that I desired to implement this to biology, to have a look at it from a physical perspective.’
Tests pseudotopological and nontopological versions for SMC-pushed DNA loop extrusion versus roadblock-traversal experiments
A lot of new phenomena were found, and he and his research group established a number one position With cees dekker this area of investigate. Dekker and his investigation group uncovered new physics of nanotubes in addition to explored the feasibility of molecular electronics. In 1998, they were being the initial to make a transistor determined by a single nanotube molecule.
Electrical transport in monolayers of phthalocyanine molecular wires and AFM imaging of one wire bridging two electrodes
Finally, I will briefly sketch some of our Suggestions to investigate the constructing of artificial cells, exclusively our initially ways to determine artificial mobile division.